Proactiv's unique formula, developed by renowned dermatologists, Katie Rodin and Kathy Fields of Stanford University, works gently on the skin to remove dead skin cells, normally clogged hair follicles, and acne-causing bacteria , to eliminate the infection. Developed by dermatological experts, Columbine is gentle and effective, and can be used on the entire face, not only to remove existing pimples, but also to prevent new small pimples from growing, even before small pimples appear on the surface of the skin. eliminate them. Proactiv's botanical formula results in healthier, better-textured, hydrated skin instead of that dry and rough feeling.